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KMID : 1123920060200061620
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Korean Journal of Oriental Physiology and Pathology
2006 Volume.20 No. 6 p.1620 ~ p.1624
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Effects of Cnidium officinale, Petasites japonicus, Coptis chinensis Extract Mixture on Vasodilation
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Kim Sang-Dae
Kim Gil-Whon
Shin Heung-Mook
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Abstract
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This study was performed to investigate a vasodilatory efficacy and its underlying mechanisms of the mixture of Cnidium officinale, Petasites japonicus and Coptis chinensis (CPC), CPC relaxed rat aortic vascular strips in endothelium-independant manner precontracted with phenylephrine or KCI(50mM), but the magnitude of relaxation was greater in KCI induced contraction. L-NAME, iNOS inhibitor, and methylen blue(MB), cGMP inhibitor, did not attenuate the relaxation responses of CPC. Furthermore, the contraction by increaseing concentration (0.3-10.0mM) to a -free high (60mM) was significantly reduced by CPC pretreatment. These results suggest that the relaxation effect of CPC is related with the block of influx via channel.
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KEYWORD
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CPC, endothelium-independent, influx, vasodilatory efficacy
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